Cystine/glutamate transporter - Wikipedia
The SLC7A11 gene encodes a sodium-independent cystine - glutamate antiporter that is chloride dependent, also known as xCT. Along with a heavy chain subunit from SLC3A2, the SLC7A11 …
xCT: A Critical Molecule That Links Cancer Metabolism to Redox ...
Nov 4, 2020 · In recent years, the xCT molecule has been found to play an important role in tumor growth, progression, metastasis, and multidrug resistance in various types of cancer. …
SLC7A11 Gene - GeneCards | XCT Protein | XCT Antibody
Nov 14, 2025 · In this system, designated Xc (-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of …
The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the ...
Feb 23, 2022 · Solute Carrier Family 7 Member 11 (SLC7A11) or xCT is the functional light chain subunit of system x c, which is a sodium-independent, chloride-dependent, anionic L-cystine/L …
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, …
The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple …
SLC7A11 expression level dictates differential responses to …
Jun 21, 2023 · The cystine transporter solute carrier family 7 member 11 (SLC7A11; also called xCT) protects cancer cells from oxidative stress and is overexpressed in many cancers.
xCT: A Critical Molecule That Links Cancer Metabolism to …
Nov 4, 2020 · In recent years, the xCT molecule has been found to play an important role in tumor growth, progression, metastasis, and multidrug resistance in various types of cancer. …
SLC7A11/xCT-mediated Cystine Uptake Regulates Intracellular …
Background/Aim: In a tongue–submandibular lymph node (SLN) metastasis model, the cystine/glutamate transporter solute carrier family 7, member 11 (Slc7a11), also known as …
A xCT role in tumour-associated ferroptosis shed light on novel ...
Oct 25, 2022 · Solute carrier family 7 member 11 (SLC7A11; also known as xCT), a key component of the cystine/glutamate antiporter, is essential for the maintenance of cellular …
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient ...
Oct 1, 2020 · The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is …