Development of robotic device for pain and somatosensory assays in rodents allows remote, quantitative, and reproducible delivery of mechanical stimuli.

This study addresses an important question in liver biology: how zonal hepatocytes balance survival and proliferation following injury; using spatial transcriptomics, mechanistic perturbations, and ...

The new program is validated in a set of clinical pedigrees demonstrating its practical accuracy and relevance to the field. Collectively, the data are compelling and support the major conclusions of ...

Alternative splicing exhibits lineage-specific variability, with mammals and birds reaching the highest levels despite conserved intron-rich architectures, while unicellular eukaryotes and prokaryotes ...

The impact of IL10 mutation in birds highlights the intrinsic compromise between effective elimination of a pathogen and damage to the host.

The effects of transcranial direct current stimulation on cortical dynamics depend on the state of consciousness and the stimulation polarity.

High-content high-resolution microscopy coupled with deep learning-based analysis reveals novel phenotypes at the single-cell level during Shigella infection.

This interesting study adapts machine learning tools to analyze movements of a chromatin locus in living cells in response to serum starvation. The machine learning approach developed is useful, the ...

A study that monitored the expression and function of designer receptors called DREADDs in macaque monkeys for a period of three years demonstrates that they are effective in long-term studies of ...

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark ...

Machine learning with whole-cell patch-clamp and local field potential recordings reveals that synaptic responses from five mossy cells, despite their limited population, can significantly reconstruct ...

This important study uses innovative microfluidics-based single-cell imaging to monitor replicative lifespan, protein localization, and intracellular iron levels in aging yeast cells. The evidence for ...