The injury-prone San Francisco 49ers are monitoring yet another health issue, this one involving quarterback Brock Purdy's ...

The San Francisco 49ers got a taste of what their defense looks like without Nick Bosa in the second half of a loss to ...

Week 11 caused a shift in power atop Sporting News' weekly in-season rankings of all the NFL teams. There was quite a 1-2 ...

San Francisco 49ers head coach Kyle Shanahan has offered an update on the injuries to Nick Bosa and Brock Purdy.

With a devastating loss in Week 11, the 49ers’ two-game win streak came to an end as they fell to 5-5 and to last place in ...

The San Francisco 49ers (5-5) meet the Green Bay Packers (7-3) in a Sunday contest at Lambeau Field. Kickoff is scheduled for ...

NFL Week 12 odds, picks, predictions, TV and streaming information for the Sunday football game between the San Francisco ...

The Seattle Seahawks have defeated the San Francisco 49ers for the first time in the post-Russell Wilson era, upsetting their ...

Any chance the 49ers have of a home playoff game would likely come by overtaking the Cardinals and winning the division title ...

The San Francisco 49ers looked to be in prime position to close out a divisional game when the defense made back-to-back ...

Star pass-catcher George Kittle and the San Francisco 49ers face the Seattle Seahawks on Sunday at 4:05 p.m. ET, at Levi’s ...