Objective Macrophage activation syndrome (MAS), a subtype of secondary haemophagocytic lymphohistiocytosis (HLH), is a rare ...

Background SLE is a chronic autoimmune disease with heterogeneous manifestations and variable outcomes. Geographic factors ...

Objective No studies have investigated the incidence and correlation of scarring and dyspigmentation across all cutaneous ...

Objective Glomerular immune complex deposition plays a central role in lupus nephritis (LN), but the prognostic relevance of individual immunoglobulin components remains unclear. This study aimed to ...

Background Systemic lupus erythematosus (SLE) is about 10 times more common among women than men. This sex bias was previously attributed to sex hormones. However, while sex hormones are abnormal in ...

Background NLRP12 (NOD-like receptor family (NLR) pyrin domain containing 12) is an innate immune check-point in regulating type I IFNs expression. Since NLRP12 may participate in the pathogenesis of ...

Background Around 963 A.D., Bishop Eraclius (Liège, Belgium) wrote an affidavit stating, ‘I … was nearly taken to death by the disease called Lupus.’ On the seventh night of praying at Saint Martin’s ...

Background Abnormalities of type I interferon signaling and production can initiate lupus development. Disturbances of nucleic acid-sensing molecules triggered autoreactivity in lupus mouse models.

Description Systemic lupus erythematosus (SLE) and atopic dermatitis (AD) are both immune disorders that can lead to significant physical complications. There have been several reports of coexistence ...

Background Systemic lupus erythematosus (SLE) often mimics the symptoms of other diseases, and the interval between symptom onset and diagnosis remains long in these patients. The aim of this study is ...

Systemic lupus erythematosus (SLE) is associated with a wide variety of ocular manifestations. Some of these include uveitis, occlusive retinal vasculitis, (epi)scleritis and keratitis. Uveitis is an ...

Background To compare disease manifestations and outcomes of juvenile-onset SLE (jSLE) and adult-onset SLE (aSLE) patients using a nested case control study of patients in a Singapore cohort. Methods ...