Microtubules -- cellular 'highways' that deliver cargo to the cell membrane for secretion -- have a surprising role in pancreatic beta cells. Instead of facilitating glucose-stimulated insulin ...
Researchers have found a switch that regulates the activity of HNF1A, a gene that causes diabetes. The study highlights potential new vulnerabilities in the disease and could lead to the development ...
Bcl-2 family regulation of neuronal cell fate plays an important role in normal mammalian nervous system development and in determining the pathological consequences of neurotoxic stimuli. However, a ...
ssDNA, which is involved in numerous aspects of chromosome biology, is managed by a suite of proteins with tailored activities. The majority of these proteins bind ssDNA indiscriminately, exhibiting ...
Mycoplasma leucyl-tRNA synthetases (LeuRSs) have been identified in which the connective polypeptide 1 (CP1) amino acid editing domain that clears mischarged tRNAs are missing (Mycoplasma mobile) or ...
Researchers at the Centre for Genomic Regulation (CRG) and Imperial College London have found a switch that regulates the activity of a gene that causes diabetes. The findings, published in Nature ...
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